Oncoplastic surgery for cutaneous head and neck cancers: A novel technique combining wide excision, local flap reconstruction and sentinel node biopsy

Abstract Background and purposes: Sentinel node biopsy (SNB) procedures in the head and neck (H&N) region can be technically demanding due to anatomic and size constraints. Often, node procurement is attempted through small incisions, making identification of crucial anatomy difficult. Given the primary site may be close to the sentinel nodes (SN), a local flap can be designed for the dual purpose of gaining access to the sentinel node field through raising the flap while facilitating repair of the primary site resulting in superior aesthetic outcomes. We detail our technique hereof. Subjects studied and methods: A review of consecutive patients undergoing [...]

October 18th, 2025|Comments Off on Oncoplastic surgery for cutaneous head and neck cancers: A novel technique combining wide excision, local flap reconstruction and sentinel node biopsy

Treatment of in-transit Merkel cell carcinoma by isolated limb infusion with cytotoxic drugs

Abstract Merkel cell carcinoma of the skin is a rare but aggressive malignancy, which predominantly affects older adults with fair skin. Isolated limb infusion (ILI) using melphalan and actinomycin D was first developed as a minimally invasive treatment option to treat unresectable metastatic melanoma confined to the limb. We report on a 62-year-old male with in-transit metastases (ITMs) treated with ILI to highlight the ongoing role this treatment has when all other therapies have been exhausted. At presentation, the patient had widespread ITMs in the right leg. Positron emission tomography scan demonstrated recurrent disease in the thigh and pelvis, [...]

April 12th, 2022|Comments Off on Treatment of in-transit Merkel cell carcinoma by isolated limb infusion with cytotoxic drugs
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