Being a world leader in melanoma research, MIA participates in, and presents projects and discoveries, at international skin cancer and oncology conferences.

March 2022

Personal risk prediction and melanoma education: an overview of patients’ experience and clinicians’ perception during the risk assessment process

Bruna Gallo, Amelia K. Smit, Andrea L. Smith, Ivy Tan, David Espinoza, Bela I. Laginha, Pascale Guitera, Linda Martin, Anne E. Cust

  • To investigate the communication between patients and clinicians regarding personal melanoma risk assessment, risk-tailored surveillance recommendations and preventive behavioural counselling conducted in the Melanoma Institute Australia (MIA) dermatology department.

Definitive treatment with PD1 blockade and radiation therapy of unresected primary desmoplastic melanoma of the nose

Caroline Asirvatham Gjorup, Ines Pires da Silva, Linda Martin, Jonathan Stretch, Richard Scolyer, Georgina V. Long, Angela Hong

  • Two patients, aged 74 and 82, with primary desmoplastic melanoma of the nose were treated with definitive anti-PD1 checkpoint inhibition and radiation therapy. While both patients were not technically unresectable, partial rhinectomies are morbidly disfiguring procedures, which both patients declined.

Skin cancer related conditions managed in general practice in Australia, 2000 to 2016 

Gillian Reyes-Marcelino, Kirstie McLoughlin, Christopher Harrison, Caroline G Watts, Yoon Jung Kang, Sanchia Aranda AM, Joanne F Aitken, Pascale Guitera, Anne E Cust

  • Solar keratoses and keratinocyte cancers are the main skin cancer related conditions managed in general practice with melanoma being the least managed. The types of skin problems encountered varied by age, gender, patient residence, language background, socioeconomic status and card holder status.

Phase III Study of Adjuvant Encorafenib Plus Binimetinib Versus Placebo In Fully Resected Stage IIB/C BRAFV600-Mutated Melanoma: COLUMBUS-AD Study Design

Alexander C. J. van Akkooi, Axel Hauschild, Georgina V. Long, Mario Mandala, Michal Kicinski, Anne-Sophie Govaerts, Isabelle Klauck, Monia Ouali, Paul C. Lorigan, Alexander M. M. Eggermont

  • The purpose of the COLUMBUS-AD (NCT05270044) study is to evaluate the efficacy and safety of 12 months of encorafenib in combination with binimetinib in the adjuvant setting of BRAF V600E/K mutant stage IIB/C melanoma versus the current standard of care (surveillance).

October 2022

Time-dependent prediction of development of melanoma brain metastases (MBM) from the start of BRAF/MEK inhibitors (BRAF/MEKi) or anti-PD-1(PD1)-based immunotherapy (IO)

Inês Pires da Silva, Ismael Vergara, Isabel Li, Serigne Lo, Matteo S. Carlino, Alexander M.
Menzies, Richard A. Scolyer, Georgina V. Long

  • To predict the likelihood of metastatic patients developing melanoma brain metastases at the start of BRAF/MEKi or PD1-based immunotherapy, and at 3, 6, 9 and 12 months thereafter.

The hypoxic microenvironment at different sites of melanoma metastasis

Jordan W. Conway, Serigne N. Lo, Ismael A. Vergara, Tuba N. Gide, Jorja Braden, Matteo S. Carlino, Robyn P.M. Saw, John F. Thompson, Andrew J. Spillane, Kerwin F. Shannon, Brindha Shivalingam1, Alexander M. Menzies, James S. Wilmott, Georgina V. Long, Richard A. Scolyer, Inês Pires Da Silva

  • To characterise and compare the hypoxic environment between different sites of metastasis
  • To provide insight into the biology of melanoma metastases at different sites of disease and identify potential mechanisms of resistance to immune checkpoint inhibitors

Spatial analysis characterises cellular immunotypes of in-transit melanoma associated with response to anti-PD1-based checkpoint inhibitor immunotherapy 

Xinyu Bai, Camelia Quek, Ines Silva, Alex Menzies, Georgina V. Long, Richard A. Scolyer, James S. Wilmott

  • To deeply characterise the TME spatial features of ITM melanoma.
  • To understand the features of primary and acquired resistance to anti-PD-based immunotherapies.
  •  To identify novel drug targets to circumvent these resistance mechanisms. 

Clinical Features Associated with Outcomes and Biomarker Analysis of Dabrafenib plus Trametinib (DT) in Patients with BRAF-Mutant Melanoma Brain Metastases (MBMs)

Wilmott JS, Tawbi H, Engh JA, Amankulor N, Shivalingam B, Banerjee H, Vergara IA, Lee H, Johansson PA, Ferguson PM, Saiag P, Robert C, Grob JJ, Butterfield LH, Scolyer RA, Kirkwood JM, Long GV, Davies MA

  • Investigating why the duration of response with DT was shorter in MBMs.

LAG-3 Expression and Outcome of Metastatic Melanoma Patients Treated with Combination Anti-LAG-3 + Anti-PD-1 Immunotherapies

T. N. Gide, E. Paver, Z. Yaseen, A. M. Menzies, J. S. Wilmott, R. A. Scolyer and G. V. Long

  • To evaluate the association between baseline LAG-3 expression and clinical outcomes following anti-LAG-3 immunotherapy in metastatic melanoma.


October 2022

NeoTrio Trial – Optimal neoadjuvant sequencing of anti-PD1 and BRAF targeting therapy in resectable BRAF mutant Stage III b/c/d Melanoma: Results of histopathological analysis.

J. Braden, A.J. Potter, E. Paver, R Rawson, A M. Menzies, M.S. Carlino, G. Au-Yeung, R.P.M. Saw, A.J. Spillane, K.F. Shannon, T. E. Pennington, S. Ch’ng, D. E. Gyorki, J. Howle, D. Daneshvar, J.S. Wilmott, S. E. Lo, I.P. Silva, R.A. Scolyer, G.V. Long

To characterise key histopathological changes with neoadjuvant targeted therapy, anti-PD-1 or combination and their association with pathological response.

October 2022

Molecular and Clinical Correlates of HER3 expression in Melanoma

E.R. Shteinman, I.A. Vergara, R.V. Rawson, S.N. Lo, N. Maeda, K. Koyama, I. Pires da Silva, G.V. Long, R.A. Scolyer, J.S. Wilmott, A.M. Menzies

To characterise the expression of HER3 in 187 melanoma biopsies across 3 TMA cohorts: the TCGA cutaneous melanoma cohort5(n = 70), the mucosal melanoma cohort (n = 38), and a cohort of cutaneous melanoma specimens taken prior to treatment with immune checkpoint blockade (ICB) therapy (pre-ICB cohort) (n = 79). HER3 expression (≥1+) was observed in 136.


September 2022

NeoPeLe: A Phase 2 Trial of Neoadjuvant Pembrolizumab Combined with Lenvatinib In Resectable Stage III Melanoma

Georgina V Long, Andrew Spillane, Thomas Pennington, Kerwin F Shannon, Jonathon R Stretch, Maria Gonzalez, Robyn PM Saw, Serigne Lo, Richard A Scolyer, Alexander M Menzies

To determine the the pathological response rate to 6 weeks of neoadjuvant pembrolizumab plus lenvatinib, and to determine the RECIST and metabolic response at week 6, the relapse free survival and to evaluate the effects on tumour tissue and peripheral blood.

September 2022

Histopathological Analysis of Neoadjuvant Sequential or Combination Targeted Therapy (TT) and anti-PD-1; Combined Analysis of NeoTrio and NeoCombi Clinical Trials

J. Braden, A.J. Potter, E. Paver, R Rawson, A M. Menzies, M.S. Carlino, G. Au-Yeung, R.P.M. Saw, A.J. Spillane, K.F. Shannon, T. E. Pennington, S. Ch’ng, D. E. Gyorki, J. Howle, D. Daneshvar, J.S. Wilmott, S. E. Lo, I.P. Silva, R.A. Scolyer, G.V. Long

To characterise key histopathological changes with neoadjuvant targeted therapy (TT), anti-PD-1 or combination and their association with pathological response.

September 2022

805P: Predicting recurrence-free survival for patients with stage II melanoma –a validated tool to guide selection for adjuvant systemic therapy

Alexander HR Varey, Mary-Ann El Sharouni, Julie Simon, Jeffrey E. Gershenwald, Georgina V. Long, Richard A. Scolyer, John F. Thompson, Serigne N. Lo

To develop a user-friendly externally validated tool for predicting relapse free survival (RFS) and overall survival (OS) in stage II melanoma patients (with or without sentinel node biopsy).

September 2022

850P: A dynamic recurrence risk prediction tool for adjuvant therapy in stage III melanoma

Amelia M Taylor, Claire Galea, Isabel Li, Alexander HR Varey, Kerwin Shannon, Sydney Ch’ng, Robyn PM Saw, Thomas Pennington, Jonathan Stretch, Andrew Spillane, Alexander C J van Akkooi, Ines P da Silva, Matteo S Carlino, Richard A Scolyer, Georgina V Long, Serigne Lo, Alexander M Menzies

To develop a web app to guide discussions about risk of recurrence with or without therapy at baseline and during a patient’s treatment journey.

September 2022

809P: Outcomes of patients with resected stage III/IV acral or mucosal melanoma treated with adjuvant anti-PD-1 therapy

Sarah Jacques, Janet McKeown, Piyush Grover, Benjamin Park, Anne Zaremba, FlorentinaDimitriou, Mohamad Farid, Kenjiro Namikawa, Megan Mooradian, Joanna Placzke, Clare Allayous, InderjitMehmi, Danielle Depalo, Alexandre Wicky, Julia Schwarze, Yasuhiro Nakamura, SeverineRoy, Alex Menzies, SerigneLo, Matteo Carlino

Determine risk of recurrence of resected acral melanomas (AM) and mucosal melanomas (MM) following adjuvant anti-PD-1, and quantify the effect of adjuvant anti-PD-1 in AM and MM compared to a historical matched cohort.

September 2022

838P: Patterns of response/progressive disease and management following progressive disease with anti PD 1 therapy in patients with advanced cutaneous Squamous Cell Carcinoma

J. Mo, S. Bohne, C. Gaudy Marqueste, N. Della Marta , L. Festino, C. Chen, S. Lo, J. Park, P. Ascierto, R. Ladwa, W. Xu, J J. Grob, A. Hauschild. A. Menzies, GV. Long, M. Carlino, I. Pires da Silva

For advanced cutaneous Squamous Cell Carcinoma evaluate site specific patterns of response to anti PD-(L)1 and study the management following progression to anti PD-(L)1.

September 2022

824P: Patterns of response/progression and management following progressive disease with anti PD –(L)1 therapy in patients with advanced Merkel Cell Carcinoma

J. Mo, A. Zaremba, J. Inderjeeth , P. El Zenaity, A. Li, A. Wicky, N. Della Marta, C. Gaudy Marqueste, S. Bohne, L. Festino, C. Chen, S. Lo, A. Guminski, O. Michielin, W. Xu, C. Lebbe, S. Sandhu, L. Zimmer, M. Carlino, I. Pires da Silva

For Merkel Cell Carcinoma evaluate site specific patterns of response of  to anti PD-(L)1 and study the management following progression to anti PD-(L)1.

ASCO 2022

June 2022

Neoadjuvant dabrafenib and trametinib (D+T) for stage III melanoma – long-term results from the NeoCombi trial

Alexander M Menzies, Robyn P M Saw, Serigne Lo, Maria Gonzalez, Sydney Ch’ng, Omgo E Nieweg, Kerwin F Shannon, Peter M Ferguson, Jenny Lee, Helen Rizos, Robert V Rawson, Jonathan R Stretch, John F Thompson, Louise Emmett, Rony Kapoor, Andrew J Spillane, Richard A Scolyer, Georgina V Long

A report of 5-year outcomes from the NeoCombi trial (NCT01972347),  for patients with resectable stage III melanoma.

June 2022

A biomarker guided Bayesian response-adaptive phase II trial for metastatic melanoma – The Personalised Immunotherapy Platform (PIP) Trial Design 

Serigne N. Lo, Tuba N. Gide, Maria Gonzalez, Ines P. da Silva, Alexander M. Menzies, Matteo S. Carlino, Richard A. Scolyer,
Stephane Heritier, James S. Wilmott, Georgina V. Long

To assess RECIST objective response rate (ORR) to 5 novel anti-PD-1 drug combinations as first and subsequent line therapy.

June 2022

Preferences for Adjuvant Immunotherapy in Patients with Resected Stage III Melanoma: A Discrete Choice Experiment (DCE)

Ann Livingstone, Alexander M Menzies, Kirsten Howard, Martin R Stockler, Rachael L Morton

A study to quantify stage III resected melanoma patient preferences and trade-offs for adjuvant immunotherapy.

June 2022

Efficacy and safety of “second adjuvant” therapy with BRAF/MEK inhibitors after resection of recurrent melanoma following adjuvant PD-1-based immunotherapy

Amelia M. Taylor, Claire Galea, Serigne N. Lo, Florentia Dimitriou, Sarah Jacques, Clara Allayous, Hui-Ling Yeoh, Julia M. Ressler, Katharina C. Kähler, Lucia Festino, Julia K. Schwarze, Alexandre M. Wicky, Joanna Placzke, Douglas B. Johnson, Lisa Zimmer, Celeste Lebbe, Reinhard Dummer, Matteo S. Carlino, Georgina V. Long, Alexander M. Menzies

A study to explore the efficacy and safety of ‘second adjuvant’ BRAF/MEKiin BRAFV600 patients who recurred despite adjuvant immunotherapy.

June 2022

VEGF inhibitors (VEGFi) activity in liver metastases (mets) regardless of primary cancer type – meta-analysis and systematic review

Inês Pires da Silva, Serigne Lo, Jordan Conway, Richard Scolyer, Matteo S. Carlino, Alexander M. Menzies, Georgina V. Long

A study to assess the efficacy of VEGFi in liver metastases utilizing randomized-controlled clinical trials (RCTs) testing the efficacy of VEGFi, regardless of primary cancer site.

June 2022

Management of infliximab refractory immune checkpoint inhibitor gastrointestinal toxicity – A multicentre case series

Harvey, C;  Nahar, K; Lo, S; Ahmed, T; Farag, S; Yousaf, N; Young, K; Tas, L; Eggink, A; Blank, C; Thomas, A; McQuade, J; Schilling, B; Johnson, DB; Martin-Huertas, R; Arance, A; Lee, J; Zimmer, L; Long, GV; Menzies, AM

A study to estimate the prevalence of patients with GI toxicity who are both steroid and IFX refractory (MIA cohort), describe the investigation and management IRIGItox, assess the efficacy of post IFX interventions and assess survival outcomes stratified by post IFX intervention.

8 April 2022

Molecular analysis finds excision margin width predictive of recurrence in acral melanoma

Grace H. Attrill, Teresa A. Bailey, Trina Lum, Jordan W. Conway, Georgina V. Long, James S. Wilmott, Richard A. Scolyer

This study aims to determine whether molecular markers can detect molecularly abnormal but histologically normal cells beyond the tumor margin, and whether such cells are associated with recurrence in acral melanoma.

16 Sept 2021

1042P: Anti-PD1 (PD1) monotherapy or in combination with ipilimumab (IPI) after BRAF/MEK inhibitors (BRAF/MEKi) in BRAF mutant metastatic melanoma (MM) patients (pts) (PDF)

Ines Pires da Silva, Danny Zakria, Tasnia Ahmed, Claudia Trojaniello, Florentia Dimitriou, Clara Allayous, Camille Gerard, Lisa Zimmer, Serigne Lo, Olivier Michielin, Celeste Lebbe, Joanna Mangana, Paolo Ascierto, Douglas B. Johnson, Matteo S. Carlino, Alexander M. Menzies, Georgina V. Long

The AIMS of this study are:
1. To determine the efficacy (objective response rare [ORR], PFS and OS) and safety of PD1 vs IPI+PD1 after BRAF/MEKi.
2. To identify the subgroup of patients with >3 years OS with PD1+/-IPI after BRAF/MEKi.

16 Sept 2021

Efficacy of checkpoint inhibitors in acral melanoma (PDF)

Prachi Bhave, Tasnia Ahmed, Alexander Shoushtari, Anne Zaremba, Judith Versluis, Joanna Mangana, Michael Weichenthal, Lu Si, Thierry Lesimple, Caroline Robert, Claudia Trojaniello, Alexandre Wicky, Richard Heywood, Lena Tran, Kathleen Batty, Anna Stansfeld, Celeste Lebbe, Julia Katharina Schwarze, Meghan Mooradian, Matteo S Carlino

A study to examine the efficacy of combination checkpoint inhibitors (CPIs) in acral melanoma (AM) compared to single agent CPI, and determine if primary AM site influences patient outcomes.

Patterns and management of progression on 1st line ipilimumab combined with anti-PD-1 (IPI+PD1) in metastatic melanoma (MM) patients (PDF)

Ines Pires da Silva, Judith M. Versluis, Tasnia Ahmed, Douglas Buckner Johnson, Jennifer Soon, Clara Allayous, Camille L. Gerard, Joanna Mangana, Oliver Klein, Lisa Zimmer, Caroline Robert, Maria Grazia Vitale, Hui-Ling Yeoh, Olivier Michielin, Celeste Lebbe, Shahneen K. Sandhu, Christian U. Blank, Matteo S. Carlino, Alexander M. Menzies, Georgina V. Long

Research from MIA’s Medical Oncologist Dr Ines Silva and her team focussed on patients whose disease progressed after first being treated with combination immunotherapy – drugs that stimulate immune cells to fight cancer. Although around half of these patients are still alive five years after starting treatment, the majority of patients will progress and may require further treatment.

IL 6 blockade for prophylaxis and management of immune related adverse events in cancer immunotherapy (PDF)

Florentia Dimitriou, Sabrina Hogan, Phil F. Cheng, Reinhard Dummer, Alexander M. Menzies, Georgina V. Long

Treatment of melanoma with immunotherapy can be lifesaving; however, it can also be complicated by significant side effects as the activated immune system cells may attack healthy cells as well. Immune cells communicate by producing small proteins, called ‘cytokines’, which co-ordinate the body’s response against inflammation. Medical Oncologist Dr Florentia Dimitriou and colleagues identified a cytokine, known as IL-6, which is increased in many inflammatory conditions.

Efficacy of Adjuvant Radiotherapy in Recurrent Melanoma after Adjuvant Immunotherapy (PDF)

Prachi Bhave, Angela Hong, Rebecca Johnson, Alexander M Menzies, Georgina V Long, Joanna Mangana, Douglas B Johnson, Zeynep Eroglu, Ozgecan Dulgar, Hui-Ling Yeoh, Andrew M Haydon, Georg Lodde, Elisabeth Livingstone, Adnan Khattak, Katharina Kahler, Axel Hauschild, Wei Wang, Matteo S Carlino

In an era where immunotherapy is now often given to reduce recurrence after surgery, Medical Oncologist Dr Prachi Bhave and colleagues at MIA investigated whether adjuvant radiotherapy is still effective in reducing melanoma recurrence. The study found that radiotherapy significantly reduced the risk of melanoma returning in nearby lymph nodes, and therefore continues to have a role in some patients whose melanoma has returned despite receiving immunotherapy after surgery.

Management of resected stage III/IV melanoma with adjuvant immunotherapy (PDF)

Rebecca Johnson, Victoria Atkinson, Prachi Bhave, Alison M. Weppler, Geoffrey David Peters, Afaf Abed, Megan Lyle, Muhammad Adnan Khattak, Andrew Mark Haydon, Matteo S. Carlino, Shahneen Kaur Sandhu, Georgina V. Long, Alexander M. Menzies

Immunotherapy after surgery for Stage III melanoma has become the standard treatment approach. This research aimed to understand who is being treated with immunotherapy across Australia, how effective the treatment was, and the variety of treatment options that are implemented if the melanoma recurs.

Poster title