The Medical Research Future Fund (MRFF) Clinical Trials Activity Initiative aims to:
- improve the evidence base supporting clinical care
- help patients access trials relevant to their health circumstances
- enable researchers to bring international trials to Australian patients.
The Medical Research Future Fund (MRFF) – 2025 Clinical Trials Activity Grant Opportunity will support medical research and medical innovation projects that:
- Stream 1 (Incubator): conduct a pilot study to assess the feasibility of a new clinical trial for one or more treatments and/or management strategies for a rare cancer, rare disease and/or unmet need.
- Stream 2 (Targeted Call for Research): conduct a clinical trial of one or more treatments and/or management-based interventions for rare cancers, rare diseases and/or unmet need.
- Stream 3 (Targeted Call for Research): conduct a clinical trial that supports the delivery of effective and high value care by targeting evidence gaps of value to health technology assessment processes in Australia.
- Stream 4 (Targeted Call for Research): conduct a prevention clinical trial aimed at reducing the risk, onset or progression of disease through early intervention strategies.
The intended outcome of the research is to improve the health and wellbeing of Australians by investing in new clinical trials that support increased access to high-quality, evidence-based and effective health care.
This grant opportunity is being administered by NHMRC on behalf of the Australian Government Department of Health, Disability and Ageing.
Key Dates
Minimum data due date: 4 March 2026
Applications close: 1 April 2026
Funding anticipated to be awarded from December 2026