Angel Guan

Can you summarise your latest research?

My current research focuses on uncovering cancer and immune vulnerabilities in Stage III melanoma patients undergoing neoadjuvant therapy. As a PhD student, I am building skills in single-cell data analysis and integrative multi-omics approaches — such as combining spatial and non-spatial single-cell data — to address complex biological questions.

How did you get into melanoma research?

During my Honours year in biochemistry, I investigated the T-lymphocyte-specific protein Lck, which sparked my interest in T cells and cancer immunotherapy. After completing that project, I knew I wanted to shift toward a more immunotherapy-focused path. To support that transition, I took a gap year to explore my interests and eventually completed an internship in a melanoma immunotherapy lab at the University of Auckland — my undergraduate institution.

What is your favourite part of your work?

I enjoy chatting with colleagues from diverse backgrounds. These interactions are not only a great way to keep learning, but they also often spark new ideas.

Do you have any future career goals?

I aim to build a skill set that will enable me to contribute meaningfully to the optimisation of immunotherapy treatments.

Describe yourself in one word:

Positive.

What is your favourite quote?

“A journey of a thousand miles begins with a single step.” — Laozi, Tao Te Ching.

I don’t always see the end of the journey, but this quote reminds me that consistent effort accumulates over time — and that through patience and persistence, transformation quietly emerges.

What is a book you’ve enjoyed recently?

The Book of Eels — Patrik Svensson.